Alpha-lipoic acid is an antioxidant made by the body. It is found in every cell, where it helps turn glucose into energy. Antioxidants attack "free radicals," waste products created when the body turns food into energy.

Clinical Applications

Epigenozyme Berberine & Alpha Lipoic Acid (ALA) supplies high potency berberine, ALA, and grape seed extract for blood sugar and cardiovascular support*. Studies indicate that berberine, a naturally found in a number of plants, is an effective supplement for helping to support cardiometabolic health*. 

*Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Glucose and Metabolic Support*

Berberine combined with alpha-lipoic acid to support healthy blood sugar metabolism, normal insulin function, lipid metabolism, and cardiovascular health.*

Provides a clinically relevant serving of 400 mg of berberine (Berberis aristata) and 100 mg of alpha-lipoic acid (ALA), to support antioxidant status, glucose metabolism, and cardiovascular health*

Vision Complete provides excellent support for those who want to maintain eye health and also for those seeking macular support as they age.*

• Provides Key Antioxidant Support for Eyes*
• Supports Macular Health*
• Helps Protects Macula Against Light Damage*
• Supports Ocular Circulation*

In the US, eye health is a major concern for those over 60 years of age. The eye is the most susceptible organ to oxidative damage caused by light, toxins (smoke), atmospheric oxygen and abrasion. As ultraviolet and blue light pass through the retina to the photoreceptors (rods and cones) and the pigmented epithelial (PE) cells, reactive oxygen species (free radicals) are generated. If there are insufficient antioxidants available to neutralize free radicals, the eye undergoes excessive oxidative damage.

Age Related Macular Degeneration (ARMD) is the number one cause of blindness in America. ARMD Eye Compelete  was formulated with a specific blend of botanicals, nutrients, antioxidants and minerals, shown in research to support healthy eye function. The formula provides antioxidant support as well as key nutrients to care for and maintain the long-term health of the eyes. 

Suggested Use: 2 capsules per day or as recommended by your health care professional.

*Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Phosphatidylserine is the most abundant phospholipid in the human brain and is made by the body in small amounts. This important phospholipid supports neuronal cell integrity by providing the building blocks needed for cell membrane structure and function.^† Cell membranes not only act as a barrier between the inside and outside of a cell, but also play an important role in cellular communication and normal cellular responses. Phosphatidylserine has also been documented to increase the availability of choline for synthesis of acetylcholine, an important neurotransmitter involved in memory and learning. It may also help enhance cognitive function by maintaining cholinergic activity in the brain.^†

^{The brain makes up only 2% of a person’s body weight, yet it consumes roughly 20% of the body’s energy when at rest. Many nutrients have been shown to support optimal neurologic and cognitive function. In addition to the well-known omega-3 fatty acid DHA, other nutrients have demonstrated efficacy in supporting cognitive function.} 

Phosphatidylserine

Phosphatidylserine (PS) is an endogenous phospholipid. Although it is less abundant in the body than other phospholipids (i.e., phosphatidylcholine and phosphatidylethanolamine), it still comprises 2–10% of the body’s total phospholipids, with critical functions in several biological areas, such as apoptosis (programmed cell death), blood clotting, and cell-to-cell communication.¹ The PS molecule consists of a glycerol-phosphate backbone, the alpha-amino acid serine, and two fatty acids. As with other phospholipids, PS is a critical component in the structure of membranes, particularly neurons.²

In the body, phospholipids form a variety of structures owing to their amphipathic nature, i.e., having both a hydrophobic  (“water-fearing”) non-polar tail and hydrophilic (“water-loving’) polar head. They can move within the fluid mosaic of cell membranes, which supports cellular communication, selective passage of macromolecules, and other important cellular functions. Phosphatidylserine is the most abundant negatively charged phospholipid in eukaryotic cell membranes.³ As the major acidic phospholipid in the brain, PS can traverse the blood-brain barrier after oral administration.⁴ In animal studies, it has been shown to influence several neurochemical systems, neuronal membranes, cell metabolism, and several neurotransmitters, including serotonin and dopamine.^†5-7  

Several clinical trials have shown that PS supplementation supports cognitive function.^†

Several clinical trials have shown that PS supplementation supports cognitive function.^† In one randomized, controlled clinical trial, 36 children, aged 4 to 14 years, who were experiencing attention-related issues were given 200 mg/d of PS or placebo for two months.⁸ PS supplementation resulted in significant improvements in attention, impulsive movement, and short-term auditory memory as compared with placebo. PS was well-tolerated and showed no adverse effects. 

Phosphatidylserine has further been shown to support healthy endocrine and adrenal responses to mental stress.^†  In a double-blind study, PS (400 mg, 600 mg, or 800 mg/d) was administered to healthy women and men 20 to 45 years old.⁹ In the groups receiving 400 mg/d of PS only, researchers observed a pronounced blunting of both serum ACTH and cortisol, and salivary cortisol responses to the Trier Social Stress Test (TSST). There was also a positive effect on emotional responses to the TSST at 400 mg/d. While the placebo group showed the expected increase in distress after the test, the group treated with 400 mg PS showed a decrease. The effect was not seen with larger doses. These results suggest that PS may dampen hypothalamic-pituitary-adrenal (HPA) axis stress responses.^† 

Phosphatidylserine also supports cognitive function in aging individuals.^† In a clinical trial, 70 elderly subjects with cognition complaints were randomly allocated to four groups: 17 patients received only social support, 18 patients received cognitive training twice a week, 17 patients received cognitive training combined with pyritinol 2 x 600 mg/d, and 18 patients received cognitive training combined with phosphatidylserine (200 mg BID). Researchers concluded that PS supplementation combined with cognitive training led to transient improvement of cognitive and memory function, as well as improved electrophysiological brain function.^†10 

*Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.